ALS Klinik çalışmalar 2011-2013

Phase III Interventional Drug Trials in ALS (US):

Stage III Trial of Ceftriaxone in ALS 
Enrolling
Multicenter
Clinicaltrials.gov Identifier: NCT00349622
http://clinicaltrials.gov/ct2/show/NCT00349622?term=ALS&recr=Open&rank=9


Phase III Study of Dexpramipexole for ALS: EMPOWER 
Active, not recruiting
Multicenter (Biogen Idec)
Clinicaltrials.gov Identifier: NCT01281189 
http://clinicaltrials.gov/ct2/show/NCT01281189?term=ALS&recr=Open&rank=210

Phase II Interventional Drug Trials in ALS (US):

Study of NP001 in subjects with ALS 
Enrolling
Multicenter (Neuraltus Pharmaceuticals, Inc)
Clinicaltrials.gov Identifier: NCT01281631 
http://clinicaltrials.gov/ct2/show/NCT01281631?term=ALS&recr=Open&rank=13


Study of CK-2017357 in Patients With ALS - Phase II 
Enrolling
Multicenter (Cytokinetics)
Clinicaltrials.gov Identifier: NCT01378676
http://clinicaltrials.gov/ct2/show/NCT01378676?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=34


Safety and Efficacy Study of Creatine and Tamoxifen in Volunteers With Amyotrophic Lateral Sclerosis
Enrolling
Multicenter
Clinicaltrials.gov Identifier: NCT01257581 
http://clinicaltrials.gov/ct2/show/NCT01257581?term=ALS&recr=Open&rank=16 


Trial of Safety and Efficacy of Rasagiline in Patients With Amyotrophic Lateral Sclerosis (ALS)
Enrolling
Multi-center
Clinicaltrials.gov Identifier: NCT01232738
  http://clinicaltrials.gov/ct2/show/NCT01232738?term=Trial+of+Safety+and+Efficacy+of+Rasagiline&rank=1

Tretinoin and Pioglitazone HCL Combination Therapy in ALS 
Enrolling
Phoenix Neurological Associates, LTD
Clinicaltrials.gov Identifier: NCT00919555
http://clinicaltrials.gov/ct2/show/NCT00919555?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=29

Interventional Trials in Familial ALS (fALS) (US):

Isis-SOD1RX Antisense Treatment in Phase 1 Clinical Trial 
Enrolling
Multicenter (Isis Pharmaceuticals, Inc)
Clinicaltrials.gov Identifier: NCT01041222
http://clinicaltrials.gov/ct2/show/NCT01041222?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=36 


Phase II/III Randomized, Placebo-controlled Trial of Arimoclomol in SOD1 Positive Familial Amyotrophic Lateral Sclerosis
Enrolling
Emory University
Clinicaltrials.gov Identifier: NCT00706147
http://clinicaltrials.gov/ct2/show/NCT00706147?term=ALS&recr=Open&rank=8


SOD1 Inhibition by Pyrimethamine in Familial Amyotrophic Lateral Sclerosis (ALS)
Enrolling
Multicenter
Clinicaltrials.gov Identifier: NCT01083667 
http://clinicaltrials.gov/ct2/show/NCT01083667?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=41

Other Interventional Trials (US):

Human Spinal Cord Derived Neural Stem Cell Transplantation for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
Active, not recruiting
Emory University
Clinicaltrials.gov Identifier: NCT01348451
http://clinicaltrials.gov/ct2/show/NCT01348451?term=Neuralstem+Study&rank=2
http://www.neurology.emory.edu/ALS/Stem%20Cell.html

High Fat/High Calorie Trial in Amyotrophic Lateral Sclerosis
Enrolling
Multi-center
Clinicaltrials.gov Identifier: NCT00983983 
http://clinicaltrials.gov/ct2/show/NCT00983983?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=2


Safety and Tolerability of the Ketogenic Diet in Amyotrophic Lateral Sclerosis (ALS)
Enrolling
John Hopkins University
Clinicaltrials.gov Identifier: NCT01016522
http://clinicaltrials.gov/ct2/show/NCT01016522?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=40 


A Randomized Crossover Study of standard NIPPV and low expiratory pressure NIPPV in ALS patients 
Enrolling
University of Michigan
Clinicaltrials.gov Identifier: NCT01154283 
http://clinicaltrials.gov/ct2/show/NCT01154283?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=47 


Effect of Noninvasive Ventilation on Lung Function in Amyotrophic Lateral Sclerosis
Enrolling
Columbia University
Clinicaltrials.gov Identifier: NCT00537446
http://clinicaltrials.gov/ct2/show/NCT00537446?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=13


Safety Study of High Doses of Zinc in ALS Patients
Enrolling
Phoenix Neurological Associates, LTD
Clinicaltrials.gov Identifier: NCT01259050 
http://clinicaltrials.gov/ct2/show/NCT01259050?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=53


EEG-Based Brain-Computer Interface Project for Individuals With Amyotrophic Lateral Sclerosis (ALS) (BCI)
Enrolling
Drexel University
Clinicaltrials.gov Identifier: NCT00718458 
http://clinicaltrials.gov/ct2/show/NCT00718458?term=ALS&recr=Open&rank=6 


Assessment of the Cyberlink Control System for Use by the Amyotrophic Lateral Sclerosis (ALS) Patient
Enrolling
Drexel University
Clinicaltrials.gov Identifier: NCT00718016
http://clinicaltrials.gov/ct2/show/NCT00718016?term=ALS&recr=Open&rank=11


BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
Enrolling
Massachusetts General Hospital 
Clinicaltrials.gov Identifier: NCT00912041 
http://clinicaltrials.gov/ct2/show/NCT00912041?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=52

Observational Research Studies in ALS (US):

ALS Gene Study
Enrolling
University of Massachusetts Medical Center
http://www.alsa.org/research/clinical-trials/als-gene-study.html


Familial Amyotrophic Lateral Sclerosis (FALS) Study
Enrolling
University of Miami
Clinicaltrials.gov Identifier: NCT00136500
http://clinicaltrials.gov/ct2/show/NCT00136500?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=20


The Pre-Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study
Enrolling
University of Miami
Clinicaltrials.gov Identifier: NCT00317616
http://clinicaltrials.gov/ct2/show/NCT00317616?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=21 


Genetics of ALS
Northwestern University
Clinicaltrials.gov Identifier: NCT00821132 
http://clinicaltrials.gov/ct2/show/NCT00821132?term=ALS&recr=Open&rank=1


Multicenter Study for the Validation of ALS Biomarkers (BIO_ALS-01)
Enrolling
Multicenter
Clinicaltrials.gov Identifier: NCT00677768
http://clinicaltrials.gov/ct2/show/NCT00677768?term=ALS&recr=Open&rank=2http://clinicaltrials.gov/ct2/show/NCT00677768?term=ALS&recr=Open&rank=2


Average Volume Assured Pressure Support (AVAPS) in ALS Patients with Nocturnal Hypoventilation: A Randomized Crossover Trial 
Enrolling
California Pacific Medical Center
http://www.alsa.org/research/clinical-management/avaps.html


Communication Study 
Enrolling
University of Washington
http://www.alsa.org/research/clinical-trials/communication-study-1.html


Development of Evidence-Based Practice Guidelines for Caregivers of Individuals with ALS and Cognitive Impairment: Pilot Study of an Educational Approach 
Enrolling
Penn State University
http://www.alsa.org/research/clinical-management/practice-guidelines.html


External nutrition in ALS patients with Ventilatory Failure: minimizing the work of breathing 
Enrolling
University of Illinois Medical Center 
http://www.alsa.org/research/clinical-management/external-nutrition-in-als.html


Optimizing NIPPV Use for Patients with ALS: Pennsylvania Consortium 
Enrolling
Multicenter
http://www.alsa.org/research/clinical-management/optimizing-nippv.html


Noninvasive Examination of the Work of Breathing in Patients With Amyotrophic Lateral Sclerosis
Enrolling
Drexel University
Clinicaltrials.gov Identifier: NCT00718003
http://clinicaltrials.gov/ct2/show/NCT00718003?term=ALS&recr=Open&rank=7


Amyotrophic Lateral Sclerosis (ALS) Tissue Donation Program
Enrolling
Drexel University
Clinicaltrials.gov Identifier: NCT00716131 
http://clinicaltrials.gov/ct2/show/NCT00716131?term=ALS&recr=Open&rank=12 


Non-Invasive Measurement of Gastrointestinal (GI) Motility in Patients With Amyotrophic Lateral Sclerosis
Enrolling
Drexel University
Clinicaltrials.gov Identifier: NCT00714805  
http://clinicaltrials.gov/ct2/show/NCT00714805?term=ALS&recr=Open&rank=15


Cortex Changes in Real/Imagined Movements in Amyotrophic Lateral Sclerosis (ALS)
Recruiting Status: unknown
University of Michigan
Clinicaltrials.gov Identifier: NCT00809224  
http://clinicaltrials.gov/ct2/show/NCT00809224?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=10


Assessment of Postural Orientation and Equilibrium In Early Amyotrophic Lateral Sclerosis (ALS)
Enrolling
Carolinas Healthcare System
Clinicaltrials.gov Identifier: NCT00956501  
http://clinicaltrials.gov/ct2/show/NCT00956501?term=Amyotrophic+Lateral+Sclerosis&recr=Open&rank=31


Collection of Blood Samples for DNA in Motor Neuron Disease
Enrolling
National Institutes of Health
Clinicaltrials.gov Identifier: NCT00362362
http://clinicaltrials.gov/ct2/show/NCT00362362?term=Collection+of+Blood+Samples+for+DNA+in+Motor+Neuron+Disease&rank=1


Kaynak